The impact of a prior SARS-CoV-2 infection on the progression of subsequent infections has
been unclear. Using a convenience sample of 94,812 longitudinal RT-qPCR measurements
from anterior nares and oropharyngeal swabs, we identified 71 individuals with two well-
sampled SARS-CoV-2 infections between March 11th, 2020, and July 28th, 2022. We
compared the SARS-CoV-2 viral kinetics of first vs. second infections in this group, adjusting
for viral variant, vaccination status, and age. Relative to first infections, second infections …

The impact of a prior SARS-CoV-2 infection on the progression of subsequent infections has
been unclear. Using a convenience sample of 94,812 longitudinal RT-qPCR measurements
from anterior nares and oropharyngeal swabs, we compared the SARS-CoV-2 viral kinetics
of first vs. second infections, adjusting for viral variant, vaccination status, and age. Relative
to first infections, second infections usually featured a lower peak viral concentration and
faster clearance time, especially in individuals who received a vaccine dose between their …