Duchenne muscular dystrophy (DMD) is a progressive muscle disease with severe cardiac
complications. It is believed that cellular oxidative stress and augmented Ca 2+ signaling
drives the development of cardiac pathology. Some mitochondrial and metabolic
dysfunctions have also been reported. Here we investigate cellular mechanisms responsible
for impaired mitochondrial metabolism in dystrophic cardiomyopathy at early stages of the
disease. We employed electrophysiological and imaging techniques to study mitochondrial …