[HTML][HTML] Decay-accelerating factor restrains complement activation and delays progression of Murine cBSA-induced membranous nephropathy
Background Complement activation is believed to play a major pathogenic role in
membranous nephropathy (MN), but its effector mechanisms are still unclear. Even less
investigated is the role of podocyte-expressed complement regulators, including decay-
accelerating factor (DAF) in disease pathophysiology. Methods We induced MN by serial
injections of cationic bovine serum albumin (cBSA) in WT, DAF−/−, and C3aR−/− BALB/c
mice and measured disease severity (by albuminuria, BUN, serum albumin, and glomerular …
membranous nephropathy (MN), but its effector mechanisms are still unclear. Even less
investigated is the role of podocyte-expressed complement regulators, including decay-
accelerating factor (DAF) in disease pathophysiology. Methods We induced MN by serial
injections of cationic bovine serum albumin (cBSA) in WT, DAF−/−, and C3aR−/− BALB/c
mice and measured disease severity (by albuminuria, BUN, serum albumin, and glomerular …
[CITATION][C] Original Investigation Decay-Accelerating Factor Restrains Complement Activation and Delays Progression of Murine cBSA-Induced Membranous …
Background Complement activation is believed to play a major pathogenic role in
membranous nephropathy (MN), but its effector mechanisms are still unclear. Even less
investigated is the role of podocyte-expressed complement regulators, including decay-
accelerating factor (DAF) in disease pathophysiology. Methods We induced MN by serial
injections of cationic bovine serum albumin (cBSA) in WT, DAF2/2, and C3aR2/2 BALB/c
mice and measured disease severity (by albuminuria, BUN, serum albumin, and glomerular …
membranous nephropathy (MN), but its effector mechanisms are still unclear. Even less
investigated is the role of podocyte-expressed complement regulators, including decay-
accelerating factor (DAF) in disease pathophysiology. Methods We induced MN by serial
injections of cationic bovine serum albumin (cBSA) in WT, DAF2/2, and C3aR2/2 BALB/c
mice and measured disease severity (by albuminuria, BUN, serum albumin, and glomerular …
