Separating the wheat from the chaff: Making sense of Treg heterogeneity for better adoptive cellular therapy

R Opstelten, D Amsen - Immunology Letters, 2021 - Elsevier
Regulatory T (Treg) cells are essential for immunological tolerance and can be used to
suppress unwanted or excessive immune responses through adoptive cellular therapy. It is
increasingly clear that many subsets of Treg cells exist, which have different functions and
reside in different locations. Treg cell therapies may benefit from tailoring the selected
subset to the tissue that must be protected as well as to characteristics of the immune
response that must be suppressed, but little attention is given to this topic in current …