[HTML][HTML] Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance
L Zhang, M DeBerge, J Wang, A Dangi, X Zhang… - American Journal of …, 2019 - Elsevier
Recipient infusion of donor apoptotic cells is an emerging strategy for inducing robust
transplantation tolerance. Daily clearance of billions of self-apoptotic cells relies on
homeostatic engagement of phagocytic receptors, in particular, receptors of the tyrosine
kinase family TAM (Tyro3, Axl, and MerTK), to maintain self-tolerance. However, an
outstanding question is if allogeneic apoptotic cells trigger the same receptor system for
inducing allogeneic tolerance. Here, we employed allogeneic apoptotic splenocytes and …
transplantation tolerance. Daily clearance of billions of self-apoptotic cells relies on
homeostatic engagement of phagocytic receptors, in particular, receptors of the tyrosine
kinase family TAM (Tyro3, Axl, and MerTK), to maintain self-tolerance. However, an
outstanding question is if allogeneic apoptotic cells trigger the same receptor system for
inducing allogeneic tolerance. Here, we employed allogeneic apoptotic splenocytes and …
