Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) signal the need
for markers of disease progression or response to therapy. This study aimed to identify
disease-associated proteins in urinary extracellular vesicles (uEVs), which include
exosomes, in patients with ADPKD. We performed quantitative proteomics on uEVs from
healthy controls and patients with ADPKD using a labeled approach and then used a label-
free approach with uEVs of different subjects (healthy controls versus patients with ADPKD …