P125 MiR-21-5P and MiR-146A-5P are deregulated in inflamed terminal ileum of treatment-naïve pediatric patients with Crohn's disease
P Jabandziev, J Kovacova, T Pinkasova… - …, 2019 - gastrojournal.org
Background Deregulation of intestinal microRNAs (miRNAs) have been reported in adult
and, in the last years, also in pediatric patients with Crohn's disease (CD). We performed a
literature search and chose 4 miRNAs from five relevant studies as candidates for an
independent validation (miR-21-5p, miR-31-5p, miR-146a-5p, miR-155-5p). The goal of this
study was to verify deregulated expression of the candidate miRNAs in inflamed terminal
ileum of treatment-naïve pediatric patients with CD. Methods We collected formalin-fixed …
and, in the last years, also in pediatric patients with Crohn's disease (CD). We performed a
literature search and chose 4 miRNAs from five relevant studies as candidates for an
independent validation (miR-21-5p, miR-31-5p, miR-146a-5p, miR-155-5p). The goal of this
study was to verify deregulated expression of the candidate miRNAs in inflamed terminal
ileum of treatment-naïve pediatric patients with CD. Methods We collected formalin-fixed …
