Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis
The Phosphatase of Regenerating Liver (PRL) proteins promote cell signaling and are
oncogenic when overexpressed. However, our understanding of PRL function came
primarily from studies with cultured cell lines aberrantly or ectopically expressing PRLs. To
define the physiological roles of the PRLs, we generated PRL2 knock-out mice to study the
effects of PRL deletion in a genetically controlled, organismal model. PRL2-deficient male
mice exhibit testicular hypotrophy and impaired spermatogenesis, leading to decreased …
oncogenic when overexpressed. However, our understanding of PRL function came
primarily from studies with cultured cell lines aberrantly or ectopically expressing PRLs. To
define the physiological roles of the PRLs, we generated PRL2 knock-out mice to study the
effects of PRL deletion in a genetically controlled, organismal model. PRL2-deficient male
mice exhibit testicular hypotrophy and impaired spermatogenesis, leading to decreased …
